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首页> 外文OA文献 >Nongenotoxic Effects And A Reduction Of The Dxr-induced Genotoxic Effects Of Helianthus Annuus Linné (sunflower) Seeds Revealed By Micronucleus Assays In Mouse Bone Marrow
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Nongenotoxic Effects And A Reduction Of The Dxr-induced Genotoxic Effects Of Helianthus Annuus Linné (sunflower) Seeds Revealed By Micronucleus Assays In Mouse Bone Marrow

机译：通过小鼠骨髓微核试验揭示向日葵向日葵种子的非遗传毒性作用和Dxr诱导的遗传毒性作用的降低

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Background: This research evaluated the genotoxicity of oil and tincture of H. annuus L. seeds using the micronucleus assay in bone marrow of mice. The interaction between these preparations and the genotoxic effects of doxorubicin (DXR) was also analysed (antigenotoxicity test) .Methods: Experimental groups were evaluated at 24-48 h post treatment with N-Nitroso-N-ethylurea (positive control - NEU), DXR (chemotherapeutic), NaCl (negative control), a sunflower tincture (THALS) and two sources of sunflower oils (POHALS and FOHALS). Antigenotoxic assays were carried out using the sunflower tincture and oils separately and in combination with NUE or DXR. Results: For THALS, analysis of the MNPCEs showed no significant differences between treatment doses (250-2,000 mg.Kg-1) and NaCl. A significant reduction in MNPCE was observed when THALS (2,000 mg.Kg-1) was administered in combination with DXR (5 mg.Kg-1). For POHALS or FOHALS, analysis of the MNPCEs also showed no significant differences between treatment doses (250-2,000 mg.Kg-1) and NaCl. However, the combination DXR + POHALS (2,000 mg.Kg-1) or DXR + FOHALS (2,000 mg.Kg-1) not contributed to the MNPCEs reduction. Conclusions: This research suggests absence of genotoxicity of THALS, dose-, time- and sex-independent, and its combination with DXR can reduce the genotoxic effects of DXR. POHALS and FOHALS also showed absence of genotoxicity, but their association with DXR showed no antigenotoxic effects. © 2014 Boriollo et al.; licensee BioMed Central Ltd.
机译：背景：这项研究使用小鼠骨髓中的微核分析法评估了油菜和H的种子的遗传毒性。还分析了这些制剂与阿霉素（DXR）的遗传毒性作用之间的相互作用（抗抗原毒性试验）。 DXR（化学疗法），NaCl（阴性对照），向日葵tin剂（THALS）和两种葵花籽油来源（POHALS和FOHALS）。分别使用向日葵tin剂和油类以及与NUE或DXR组合进行抗原毒性试验。结果：对于THALS，对MNPCE的分析显示，治疗剂量（250-2,000 mg.Kg-1）和NaCl之间无显着差异。当THALS（2,000 mg.Kg-1）与DXR（5 mg.Kg-1）组合使用时，观察到MNPCE显着降低。对于POHALS或FOHALS，对MNPCE的分析也显示治疗剂量（250-2,000 mg.Kg-1）和NaCl之间没有显着差异。但是，DXR + POHALS（2,000 mg.Kg-1）或DXR + FOHALS（2,000 mg.Kg-1）的组合不能降低MNPCEs。结论：这项研究表明，THALS没有遗传毒性，不受剂量，时间和性别的影响，并且与DXR联用可降低DXR的遗传毒性作用。 POHALS和FOHALS也显示没有遗传毒性，但是它们与DXR的结合没有显示出抗原毒性作用。 ©2014 Boriollo等；被许可人BioMed Central Ltd.

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